Yes I am unable to reach all my domain's that use eNom DNS. Their IP loads fine directly, so does domains using my name servers but not theirs. I am also unable to reach eNom.com. I can't even tracert, no hostname found.
I am using Comcast in Arizona and I can load my domains and enom using various proxy services. I have a customer who also can't reach their domain from Florida.
Are you still having issues?