"How likely is it that you would lose the domain name?"
It will depend largely on the "aroma" of legitimacy than whether you can think up some sort of acronymic correspondence.
Please excuse the redundancy, but some of these issues are perennial. Take a guy who lives a stone's throw from the Wake Forest University Baptist Medical Center who one morning decides to start the "Web Forum for Unaffiliated Business Management Consultants".....
http://www.arb-forum.com/domains/decisions/125751.htm
I still scratch my head wondering what the heck an "unaffiliated business management consultant" might be, or why they might want a "web forum" for doing this unaffiliated consulting.
Then there was the famous "Mud Sweats Downhill World" (msdw) case, where the domain registrant just "incidentally" happened to have morganstanleydirect.com name...
http://www.rbd-law.com/domain_names/court_cases/msdwonline-com.htm
Credible acronymic uses, versus something that someone made up on an ad-hoc, or worse post-hoc, basis, are sorted out on the basis of the Panel's gut feel. For example, whether one recognizes "PWC" as the generic acronym for personal watercraft, or as a trademark for Price Waterhouse Coopers, can depend on what one's hobbies happen to be. In general, the longer the acronym, say five letters or so, the more difficult it is going to be for a panelist to accept that the correspondence between your obscure acronym and a famous trademark is just a coincidence.
When you see a domain name that is four-letters long and begins with a K or a W, then you might wonder right off the bat whether the domain name registrant lives in the broadcast area of a US radio or television station that uses those four letters as its call sign.
Another example - PRADA - Italian Design House or acronym for "Public Relations and Design Analysis"?
http://arbiter.wipo.int/domains/decisions/html/2001/d2001-1090.html
None of these cases boil down to "can the domain name be an acronym for something else" - of course it can. What the cases boil down to is "what is really going on here?" and "what other relevant behavior is or is not present?"